COBE Constraints on a Compact Toroidal Low-density Universe

In this paper, the cosmic microwave background (CMB) anisotropy in a multiply-connected compact flat 3-torus model with the cosmological constant is investigated. Using the COBE-DMR 4-year data, a full Bayesian analysis revealed that the constraint on the topology of the flat 3-torus model with low-matter-density is less stringent. As in compact hyperbolic models, the large-angle temperature fluctuations can be produced as the gravitational potential decays at the $\Lambda$-dominant epoch well after the last scattering. The maximum allowed number $N$ of images of the cell (fundamental domain) within the observable region at present is approximately 49 for $\Omega_m=0.1$ and $\Omega_\Lambda=0.9$ whereas $N\sim8$ for $\Omega_m=1.0$ and $\Omega_\Lambda=0$.Comment: 13 pages using RevTeX, 5 eps files, typos correcte

Accomplishments, engagements and new challenges for the Monaldi Archives for Chest Disease

The Editors: Antonio Spanevello, Bruno Balbi Another year has passed, and we would like to thank and recognize all of the many members who have contributed to the editorial process and content of Monaldi during 2018. Our submissions are increasing, citations for our papers are rising, and recognition of the journal is broadening. Not settled for focusing on past goings-on only, we now direct our efforts toward building an even greater impact

A new Editorial Board of Monaldi Archives for Chest Disease

In recent years, Monaldi has reached a widespread diffusion and consolidated its reputation as a good quality scientific journal in the field of cardiopulmonary rehabilitation. Many of these achievements are due to the hard work of many pulmonary physicians, most of them, including the last two former Editors, Claudio F. Donner and Ciro Rampulla, part of the FSM and distinguished leaders of research groups in their field. Commercing in 2002, Monaldi has divided the published issues in a Cardiologic and in a Pulmonary Series, issued separately. This year, FSM decided to renew also the Editorial Board of the Pulmonary series. Beginning with the present issue we (Antonio Spanevello and Bruno Balbi) are the two new Co-Editors. We are currently Head and Scientific Secretary, respectively, of the Pulmonary Rehabilitation Department, the organization that comprises the Pulmonary Physicians working at FSM. As Editors we will work together with two Deputy Editors (Dr. Mirco Lusuardi, Head of Pulmonary Rehabilitation, Health Authority of Reggio Emilia and Dr. Maurizio Luisetti, Head of Biochemistry and Genetics in Pulmonary Medicine, University of Pavia) and two Executive Editors (Dr. Giuseppe Brunetti and Dr. Luca Bianchi, both at FSM). This \u201cunder fifty\u201d Editorial Board, is deeply committed to doing the best for our Journal and to continue and extend the precious work done by the previous Editors. We heritage a healthy and well-nourished scientific journal. It is an honor and a privilege to take over as Editors from Ciro Rampulla and we thank him for his wise and culturally rich contribution to Monaldi. As Editor in Chief of the past Editorial Board in the last 2 years Ciro worked hard and refined the editorial and administrative procedures, with the full support of the FSM. His example will be a guide for us to chair the Editorial Board of the Journal

Searching for a dipole modulation in the large-scale structure of the Universe

Several statistical anomalies in the CMB temperature anisotropies seem to defy the assumption of a homogeneous and isotropic universe. In particular, a dipole modulation has been detected both in WMAP and Planck data. We adapt the methodology proposed by Eriksen et al. (2007) on CMB data to galaxy surveys, tracing the large-scale structure. We analyse the NRAO VLA Sky Survey (NVSS) data at a resolution of ~2 degrees for three different flux thresholds: 2.5, 5.0 and 10.0 mJy respectively. No evidence of a dipole modulation is found. This result suggests that the origin of the dipole asymmetry found in the CMB cannot be assigned to secondary anisotropies produced at redshifts around z = 1. However, it could still have been generated at redshifts higher or lower, such as the integrated Sachs-Wolfe effect produced by the local structures. Other all-sky surveys, like the infrared WISE catalogue, could help to explore with a high sensitivity a redshift interval closer than the one probed with NVSS.Comment: 6 pages, 2 figures. Some minor changes have been done from the original manuscript. This paper is accepted by MNRA

The Habitability of the Galactic Bulge

We present a new investigation of the habitability of the Milky Way bulge, that expands previous studies on the Galactic Habitable Zone. We discuss existing knowledge on the abundance of planets in the bulge, metallicity and the possible frequency of rocky planets, orbital stability and encounters, and the possibility of planets around the central supermassive black hole. We focus on two aspects that can present substantial differences with respect to the environment in the disk: (i) the ionizing radiation environment, due to the presence of the central black hole and to the highest rate of supernovae explosions and (ii) the efficiency of putative lithopanspermia mechanism for the diffusion of life between stellar systems. We use analytical models of the star density in the bulge to provide estimates of the rate of catastrophic events and of the diffusion timescales for life over interstellar distances.Comment: Published in Lif

Bacterial–viral load and the immune response in stable and exacerbated COPD: Significance and therapeutic prospects

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation and an abnormal inflammatory response of the lung. Bacteria and viruses are a major cause of COPD exacerbations and may contribute to COPD progression by perpetuating the inflammatory response in the airways. Bacterial variety diminishes with increasing COPD severity. Respiratory viruses can colonize the lower respiratory tract in stable COPD, altering the respiratory microbiome and facilitating secondary bacterial infections. In this review, we present the most updated information about the role of bacteria and viruses in stable and exacerbated COPD. In our opinion, to optimize therapeutic strategies, the dynamic events involving bacterial–viral infections and related immune response in COPD phenotypes need to be better clarified. Our paper would address these points that we consider of great importance for the clinical management of COPD